New strategies for allogeneic BMT
نویسندگان
چکیده
منابع مشابه
Dli after Allogeneic Bmt for Scd
Volume 40, September 2000 TRANSFUSION 1071 Sickle cell disease (SCD) may be associated with considerable morbidity and mortality, particularly as patients reach adulthood.1 Among the various therapeutic options, allogeneic HPC transplantation is the only treatment with proven curative potential.1,2 However, the underlying disease recurs in about 10 percent of patients.2 Donor lymphocyte infusio...
متن کاملDoubling down on PKC benefits allogeneic BMT.
integrin (see figure). The binding of Kindlin to the integrin induces a conformational change in the integrin tail that facilitates the integrin to bind to another protein called Talin. Together, the binding of Kindlin and Talin to an integrin induces changes that allow the integrin to bind to its ligand. Until now, it appeared that the Kindlin-associated diseases—Kindler syndrome and leukocyte...
متن کاملChronic GvHD decreases antiviral immune responses in allogeneic BMT.
Chronic graft-versus-host disease (cGvHD) is associated with functional immunodeficiency and an increased risk of opportunistic infections in allogeneic bone marrow transplantation (BMT). We used a parent to F1 model of allogeneic BMT to test the hypothesis that cGvHD leads to impaired antigen-specific antiviral immunity and compared BM transplant recipients with cGvHD to control groups of allo...
متن کاملAllogeneic cell therapy: the treatment of choice for all hematologic malignancies relapsing post BMT.
I read the article of Hans J. Kolb on behalf of the European Group for Blood and M m w Transplantation working party with great interest.’ This article attempts to summarize the present state of the art in treating relapsed leukemia following allogeneic bone marrow transplantation (BMT) with donor lymphocyte infusion. Ignoring previously published observations have lead the authors to a number ...
متن کاملA novel application of cyclosporine A in nonmyeloablative pretransplant host conditioning for allogeneic BMT.
The treatment of mice with anti-CD4 and anti-CD8 monoclonal antibodies (mAbs) on day -5, plus 3 Gy whole body irradiation (WBI) and 7 Gy thymic irradiation (TI) on day 0, allows fully major-histocompatibility-complex-mismatched allogeneic bone marrow engraftment and the induction of immunologic tolerance. TI is required in this model to overcome alloreactivity and possibly to make "space" in th...
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ژورنال
عنوان ژورنال: Bone Marrow Transplantation
سال: 2003
ISSN: 0268-3369,1476-5365
DOI: 10.1038/sj.bmt.1703948